Correlation between Insulin Resistance and Severity of Coronary Artery Disease in Non-diabetes

Objective: There is an increased risk of coronary artery disease (CAD) in both diabetes and non-diabetes. Insulin resistance (IR) has been associated with the development of CAD in this both populations. However, there are not many studies on correlation between IR and severity of CAD in nondiabetes. This study aimed to establish a correlation between IR and severity of CAD in non-diabetic individuals. Methods: A cross-sectional study of 79 consecutive non-diabetic patients undergoing coronary angiogram for evaluation of clinically suspected CAD at a tertiary care hospital in Mangalore, Karnataka, were recruited. Clinical history, anthropometric, and biochemical parameters were analyzed. IR was determined by homeostasis model assessment-IR (HOMA-IR). The severity of CAD was assessed by Modified Gensini score. A Pearson correlation was done to find out the relation between HOMA-IR and Gensini core. Results: The correlation between log of HOMA-IR and severity of CAD as assessed by Gensini score (r=−0.053 and p=0.64) was not significant in nondiabetic patients. The correlations between severity of CAD and other known risk factors of CAD were also was not significant. Conclusions: HOMA-IR is negatively associated with severity of CAD in non-diabetes.